GF109203X 133052-90-1

GF-109203X

分子式：C25H24N4O2   分子量：412.48

 

产品描述

GF109203X是有效的PKCYZ剂，YZPKCα, PKCβI, PKCβII,和PKCγ,IC50分别为20 nM, 17 nM, 16nM, 和 20 nM，作用于PKC比作用于EGFR, PDGFR和胰岛素受体选择性高3000倍以上。

靶点

PKCα PKCβI PKCβII PKCγ    

IC50

20 nM 17 nM 16 nM 20 nM    

体外研究

GF109203X, as an ATP-competitive PKC inhibitor, prevents platelet aggregation induced by stimuli that activate PKC, ａnd has the potential as a tool for studying the involvement of PKC in signal transduction pathways. [1] GF 109203X produces reversal activity on P-glycoprotein ａnd MRP -mediated multidrug resistance. [2] [3] PKC inhibition by GF109203X significantly reduces carbachol-stimulated ERK1/2 activation ａnd the subsequent proliferation of SNU-407 colon cancer cells. [ - See more at: http://www.selleckchem.com/products/gf109203x.html#sthash.sDMz4BKs.dpuf

体内研究

 

溶解性

DMSO 82 mg/mL，水 <1 mg/mL，乙醇 <1 mg/mL

稳定性

2年 -20°C粉状，6月-80°C溶于DMSO