产品库
登录
首页 找仪器 社区 百科 新品 供应商 品牌 应用 资料 仪企号 展会 标准 求购 招中标

FITC标记的磷酸化系统性红斑狼疮先关蛋白TREX1抗体

产品信息
FITC标记的磷酸化系统性红斑狼疮先关蛋白TREX1抗体产品介绍：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
 
英文名称 Anti-phospho-ATRIP (Ser68+Ser72)/FITC
中文名称 FITC标记的磷酸化系统性红斑狼疮先关蛋白TREX1抗体
别    名 ATRIP (phospho S68 + S72); Phospho-ATRIP (Ser68 + Ser72); P-ATRIP (phospho-Ser68/Ser72); AGS 1; AGS1; AGS-1; Aicardi Goutieres syndrome 1; ATIP; ATM ａnd Rad3 related interacting protein; ATM ａnd Rad3-related-interacting protein; ATR interacting protein; ATR-interacting protein; Atrip; ATRIP_HUMAN; Deoxyribonuclease III dnaQ/mutD (E. coli) like; DKFZp434J0310; DKFZp762J2115; DNase III; DRN 3; DRN3; FLJ12343; MGC20625; MGC26740; Three prime repair exonuclease 1; TREX 1; TREX1; TREX1 protein; MGC21482; 3＇ repair exonuclease 1; 3＇-5＇ exonuclease TREX1.
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 免疫学  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 86kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human ATRIP around the phosphorylation site of Ser68 + Ser72 [LA(p-S)QAL(p-S)QC]
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
DNA damage or incomplete replication of DNA results in the inhibition of cell cycle progression at the G1 to S or the G2 to M phase transition by conserved regulatory mechanisms known as cell cycle checkpoints. Checkpoint proteins include Rad17, which is involved in regulating cell cycle progression at the G1 checkpoint as well as Chk1, Chk2, Rad1, Rad9 ａnd Hus1, which are involved in regulating cell cycle arrest at the G2 checkpoint. In response to DNA damage, ATM ａnd ATR kinases are important for cell cycle checkpoint response signalling. ATR-interacting protein (ATRIP), also designated ATM ａnd Rad3-related-interacting protein, is required for checkpoint signaling after DNA damage. It is also important for ATR expression, which regulates DNA replication ａnd damage checkpoint responses. ATRIP is a ubiquitously expressed protein that can form heterodimers with ATR. After dimerization they bind the RPA complex ａnd are recruited to single stranded DNA. ATRIP is a nuclear protein that may also play a role in protein stabilization. 

Function:
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. 

信息声明：本产品供应信息由仪器网为您整合，供应商为（江苏酶联生物科技有限公司），内容包括 （FITC标记的磷酸化系统性红斑狼疮先关蛋白TREX1抗体）的品牌、型号、技术参数、详细介绍等；如果您想了解更多关于 （FITC标记的磷酸化系统性红斑狼疮先关蛋白TREX1抗体）的信息，请直接联系供应商，给供应商留言！
供应商产品推荐
    您可能感兴趣的产品