PRO-305 PTEN Human/重组人磷酸酶张力蛋白同系物
- 产地：美洲
- 供应商：厦门慧嘉生物科技有限公司
- 供应商报价：电议
- 标签：PRO-305 PTEN Human/重组人磷酸酶张力蛋白同系物,生物试剂,生化试剂,供应PRO-305 PTEN Human/重组人磷酸酶张力蛋白同系物,厦门慧嘉生物科技有限公司
产品库
| Synonyms | Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase ａnd dual-specificity protein phosphatase PTEN, EC 3.1.3.67, EC 3.1.3.16, EC 3.1.3.48, Phosphatase ａnd tensin homolog, Mutated in multiple advanced cancers 1, PTEN, MMAC1, TEP1, BZS, MHAM, PTEN1, 10q23del, MGC11227. |
| Introduction | PTEN, a tumor suppressor, has been implicated in a large number of human tumors ａnd is conserved from humans to worms. PTEN has a tensin like domain ａnd a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. characterization of PTEN protein showed that it is a phosphatase that acts on proteins ａnd on 3-phosphorylated phosphoinositides, ａnd can therefore modulate signal transduction pathways that involve lipid second messengers. In contrast to most of the protein tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells ａnd acts as a tumor suppressor by negative regulation of AKT/PKB signaling pathway. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, ａnd thus influence cell survival signaling. |
| Description | PTEN Human Recombinant full length protein expressed in E.coli, shows a 86 kDa band on SDS-PAGE（including GST tag） ａnd it is antibody reactive. The PTEN is purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered clear solution. |
| Formulation | PTEN in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% glycerol. |
| Stability | Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles. |
| Applications | ? ELISA ? Inhibition Assays ? Western Blotting. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
