PRO-688 SLC4A4 Human/重组人溶质载体家族4，碳酸氢
- 产地：美洲
- 供应商：厦门慧嘉生物科技有限公司
- 供应商报价：电议
- 标签：PRO-688 SLC4A4 Human/重组人溶质载体家族4，碳酸氢,生物试剂,生化试剂,供应PRO-688 SLC4A4 Human/重组人溶质载体家族4，碳酸氢,厦门慧嘉生物科技有限公司
产品库
| Synonyms | KNBC, NBC1, NBC2, Pnbc, HNBC1, hhNMC, SLC4A5, DKFZp781H1314, SLC4A4, Electrogenic sodium bicarbonate cotransporter 1, Sodium bicarbonate cotransporter, Na（+）/HCO3（-） cotransporter, Solute carrier family 4 member 4, kNBC1, NBC, NBCE1. |
| Introduction | SLC4A4 takes part in the regulation of bicarbonate secretion ａnd absorption ａnd intracellular pH. Mutations in SLC4A4 gene are associated with proximal renal tubular acidosis. SLC4A4 is involved in the regulation of intracellular pH in several cell types. SLC4A4 Isoform 2 is particularly expressed in kidney at the level of proximal tubules. Amino acid subsitution in SLC4A4 results in an increase of chloride transport. NBC1 takes part in proximal renal tubular acidosis ａnd ocular abnormalities. |
| Description | SLC4A4 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 460 amino acids （1-424 a.a.） ａnd having a molecular mass of 51.5 kDa. SLC4A4 is fused to 37 amino acid His Tag at N-terminus ａnd purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless solution. |
| Formulation | The SLC4A4 protein solution contains 20mM Tris-HCl, pH-7.5, 0.5mM DTT, 0.1mM PMSF ａnd 10% glycerol. |
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles. |
| Purity | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSTE NVEGKPSNLG ERGRARSSTF LRVVQPMFNH SIFTSAVSPA AERIRFILGEEDDSPAPPQL FTELDELLAV DGQEMEWKET ARWIKFEEKV EQGGERWSKP HVATLSLHSL FELRTCMEKG SIMLDREASS LPQLVEMIVDHQIETGLLKP ELKDKVTYTL LRKHRHQTKK SNLRSLADIG KTVSSASRMF TNPDNGSPAM THRNLTSSSL NDISDKPEKD QLKNKFMKKLPRDAEASNVL VGEVDFLDTP FIAFVRLQQA VMLGALTEVP VPTRFLFILL GPKGKAKSYH EIGRAIATLM SDEVFHDIAY KAKDRHDLIAGIDEFLDEVI VLPPGEWDPA IRIEPPKSLP SSDKRKNMYS GGENVQMNGD TPHDGGHGGG GHGDCEELQR TGRFCGGLIK DIKRKAPFFA SDFYDALNIQ. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
