PRO-705 TBCA Human/重组人微观蛋白折叠辅因子A
- 产地：美洲
- 供应商：厦门慧嘉生物科技有限公司
- 供应商报价：电议
- 标签：PRO-705 TBCA Human/重组人微观蛋白折叠辅因子A,生物试剂,生化试剂,供应PRO-705 TBCA Human/重组人微观蛋白折叠辅因子A,厦门慧嘉生物科技有限公司
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| Synonyms | Tubulin-specific chaperone A, Tubulin-folding cofactor A, CFA, TCP1-chaperonin cofactor A, TBCA. |
| Introduction | TBCA is a tubulin-folding protein which is involved in the early step of the tubulin folding pathway. TBCA is one of four proteins （cofactors A, D, E, ａnd C） implicated in the pathway directing to properly folded beta-tubulin from folding intermediates. Cofactors A ａnd D are thought to be a factor in capturing ａnd stabilizing beta-tubulin in a quasi-native confirmation. TBCA is crucial for cell viability, if reduced it causes a decrease in the amount of soluble tubulin, alterations in microtubules ａnd G1 cell cycle arrest. Cofactor E attaches to the cofactor D-tubulin complex, afterward, interaction with cofactor C triggers the release of tubulin polypeptides that are committed to the native state. |
| Description | TBCA Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 108 amino acids （1-108 a.a.） ａnd having a molecular mass of 12.8 kDa. The TBCA is purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered colorless solution. |
| Formulation | The TBCA solution contains 20mM Tris-HCl buffer pH 7.5, 1mM DTT ａnd 10% glycerol. |
| Stability | TBCA although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. |
| Purity | Greater than 95.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE. |
| Amino acid sequence | MADPRVRQIK IKTGVVKRLV KEKVMYEKEA KQQEEKIEKM RAEDGENYDI KKQAEILQES RMMIPDCQRR LEAAYLDLQR ILENEKDLEE AEEYKEARLV LDSVKLEA. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
