"Recombinant Human TGF-β2 Peprotech 原装" 报价/价格

Recombinant Human TGF-β2 (mammalian derived)
产品编号:
100-35B
别名:
Transforming Growth Factor-β2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin
描述:
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
氨基酸序列:
ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS
来源:
HEK293 cells
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The was found to be ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
交叉反应:
Mouse, Rat
研究领域:

	血管生成/ 心血管		细胞凋亡
	癌症		免疫系统
	炎症		增殖
	干细胞及分化		TGF超家族
	创伤修复		过敏

原产国:
USA
仅用于研究。不适用于诊断或ZL。