广州创仑 TOP2A基因检测试剂盒 荧光原位杂交法

TOP2A基因检测试剂盒 荧光原位杂交法 

广州健仑生物科技有限公司

我司还有很多荧光原位杂交系列检测试剂盒以及各种FISH基因探针和染色体探针等，。

蒽环类药物靶点TOP2A和HER2存在共表达性,HER2基因高表达时,TOP2A趋向于高表达(P=0.01)。PTEN表达与TOP2A表达无统计学差异性关系。PI3K突变与TOP2A表达存在正相关关系,PI3K突变时TOP2A趋向于高表达(P=0.004)。TOP2A基因检测试剂盒 荧光原位杂交法

 以确诊为乳腺癌患者的石蜡包埋乳腺癌组织切片为检测对象，用荧光原位杂交的方法检测乳腺癌细胞中TOP2A基因的状态，作为预后判断以及指导乳腺癌化疗及药物ZL尤其是含蒽环类药物的ZL方案ZL的一项辅助检测手段。

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 以下是我司出售的部分FISH产品：

The human genes of C-erbB-2 and Her-2 are discovered because they are similar to retrovirus V - erbB-2. After Coussens L and Schechte AL, Neu, Her-2, C-erbB-2 were sequenced and chromosomal location analysis proved that they were the same gene.
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The human gene is located on chromosome 17q12, and its encoded product is 185kD transmembrane protamine p185, which is composed of 1255 amino acids. The 720 to 987 belongs to the tyrosine kinase region. Her-2/neu protein is a tyrosine protein kinase active transmembrane glycoprotein and is one of the members of the EGFR family.
Her-2/neu protein by extracellular ligand binding region, a single transmembrane region and intracellular protein tyrosine kinase domain is composed of three parts, because has not yet found the ligand can bind directly to Her-2/neu protein. It mainly through other members with family including EGFR (HERl/erbBI), HER3/ erbB3. HER4/erbB4 forms an isooligomer and combines with the respective ligands. The Her-2/neu protein is often the preferred mate of the isomer, and the activity is often stronger than the other iso - two - polymer. When binding to the ligand, the activity of tyrosine kinase is activated mainly by causing the receptor dimerization and the autophosphorylation of the tyrosine kinase region in the cytoplasm.
It has been shown that overexpression of HRE-2 can potentially activate EGFR signaling pathways, and also promote EGFR mediated transformation and tumor formation.