CON021 µ-conotoxin CnIIIC（u-芋螺毒素 CnII...

 µ-conotoxin CnIIIC（µ-芋螺毒素 CnIIIC）

Selective blocker of Na_v1.4 channels(钠离子通道Na_v1.4选择性阻断剂)

µ-conotoxin CnIIIC has been isolated from the venom of the marine cone snail Conus consors. µ-conotoxin CnIIICexhibits a myorelaxing effect through specific blockade of the skeletal muscle Na_v1.4 channels (IC₅₀ = 1.4 nM). µ-conotoxin CnIIIC also blocks Na_v1.2 channels (1 µM) and mildly Na_v1.7. In contrast, Na_v1.5 and Na_v1.8 are insensitive to the action of the toxin. µ-conotoxin CnIIIC also blocks the α3β2 nicotinic acetylcholine receptor (IC₅₀ = 450 nM) and to lesser extents the α7 and α4β2 subtypes. µ-conotoxin CnIIIC compley inhibits twitch tension in isolated mouse hemidiaphragms (IC₅₀ = 150 nM).

µ-conotoxin CnIIIC 技术资料

氨基酸序列：Pyr-Gly-Cys³-Cys⁴-Asn-Gly-Pro-Lys-Gly-Cys¹⁰-Ser-Ser-Lys-Trp-Cys¹⁵-Arg-Asp-His-Ala-Arg-Cys²¹-Cys²²-NH2 

二硫键：Cys³-Cys¹⁵, Cys⁴-Cys²¹ and Cys¹⁰-Cys²² 

长度 (aa)： 22 

分子式： C₉₂H₁₄₁N₃₅O₂₈S₆ 

分子量：2375.8 Da 

外观：White lyophilized solid 

可溶性：water and saline buffer 

CAS 号：not available 

来源：Synthetic  

纯度：> 97 % 
 

产品信息