Recombinant Mouse Progranulin (Untagged)

Recombinant Mouse Progranulin (Untagged)
Product Name: Recombinant Mouse Progranulin (Untagged)
Alternate Name/Synonyms: Proepithelin, PEPI, PC Cell-derived Growth Factor.
Gene Symbol: GRN
Accession #: P28798
Gene ID: 10090
Source: HEK 293 cells
Appearance: Lyophilized protein
Physical Form Description: Lyophilized from 0.2 μm-filtered solution in PBS, pH 7.2.
Molecular Weight: ~65.0 kDa
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: <0.1 EU/µg purified protein
Biological Activity: N/A
Reconstitution Instructions: Reconstitute in distilled water
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Amino Acid Sequence: Signal peptide and mouse progranulin (aa 1-589) is untagged. Reflects the native sequence with no additional amino acids.
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.