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20062 Immunization grade mouse type II co...

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Collagen Induced Arthritis - Collagen
Chondrex provides various species and types of highly purifi ed cartilage collagen, type II, IX, and XI collagen, which are suitable for the induction of Collagen-Induced Arthritis （CIA） and various applications such as bioengineering of artifi cial cartilage and cell cultures. CIA can be induced in rodents and non-human primates by immunization with type II collagen, but it has been reported that type XI is also capable of inducing arthritis in mice and rats, since the alpha 3（XI） chain of type XI collagen is identical with the alpha 1（II） chain of type II collagen. Furthermore, it has been suggested that autoantibodies to type IX collagen may contribute to polychondritis development in mice. Choose the appropriate species and types of collagen for individual experimental purposes.
Type II Collagen

Species
Quantity
Catalog #
Bovine
10 mg, lyophilized
20021
Bovine
2 mg/ml x 5 ml
20022
Chick
10 mg, lyophilized
20011
Chick
2 mg/ml x 5 ml
20012
Goat
5 mg, lyophilized
20071
Human
1 mg, lyophilized
20051
Human
2 mg/ml x 0.5 ml
20052
Mouse
1 mg, lyophilized
20061
Mouse
2 mg/ml x 0.5 ml
20062
Porcine
10 mg, lyophilized
20031
Porcine
2 mg/ml x 5 ml
20032
Rat
5 mg, lyophilized
20041
Rat
2 mg/ml x 2.5 ml
20042
Sheep
5 mg, lyophilized
20081
Type IX Collagen

Species
Quantity
Catalog #
Bovine
5 mg, lyophilized
1072
Chick
5 mg, lyophilized
1071
Human
1 mg, lyophilized
1075
Porcine
5 mg, lyophilized
1073
Type XI Collagen

Species
Quantity
Catalog #
Bovine
5 mg, lyophilized
1082
Chick
5 mg, lyophilized
1081
Human
1 mg, lyophilized
1085
Porcine
5 mg, lyophilized
1083
Combination of MHC Types and Species of Collagen for Inducing CIA
Collagen-induced arthritis （CIA） can be induced in certain strains of mice, rats, and non-human primates by immunization with type II collagen emulsified with adjuvant. Susceptibility to CIA in rodents is linked to MHC class II molecules of animals, but also depends on the species of type II collagen used for immunization. Choose the appropriate species of type II collagen for inducing CIA according to the table below. Importantly, homologous type II collagen is not capable of inducing CIA by an ordinary immunization schedule.
 
Two Factors that should be considered by Users of Animal Models
Animal models have contributed to remarkable advances in the understanding of numerous human diseases. As invaluable as animal models are, some drawbacks do exist. One such drawback stems from the different sources of variability which can affect the outcome of the experiments. Therefore, a pilot study is generally recommended for first time users of all animal models. A brief discussion of the 2 main points of variability will be explained below.
1. Mouse Vendors
The genetic background of mice, even in the same strain, will vary from vendor to vendor and can affect how the animals respond to various reagents, thus impacting the results of your experiment （1）. Therefore, testing animals from different vendors using a defined protocol is recommended before proceeding with a large full-scale experiment.
2. Housing Conditions
The bacteria flora is very important to the health of the animal, including the proper functioning of the immune system （1）. Therefore, we recommend housing animals in Specific Pathogen Free （SPF） conditions rather than conventional conditions to avoid variability caused by bacteria.
Overall, special consideration of these main points of variability will aid the researcher in completing their experiments with less confounding results.
References
1. Ivanov II. et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139（3）: 485-498 （2009
 
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