标准品 烟曲霉素/Fumagillin Standard
- 品牌：Fermentek
- 型号：标准品
- 产地：Fermentek
- 供应商：广州市齐云生物技术有限公司
- 供应商报价：1800
- 标签：烟曲霉素/Fumagillin Standard,1800,广州市齐云生物技术有限公司
产品库
烟曲霉素/Fumagillin Standard
| Source: | Aspergillus fumigatus |
| Synonyms | Fumidil B, Amebacilin, |
| Description: | Fumagillin : Antiamoebic. Inhibitor of angiogenesis. Attention: The Research grade （98% or better） Fumagillin is |
| CAS number: | 23110-15-8 |
| Merck index: | 13, 4307 |
| Molecular weight: | 458.6 |
| Structure: |
|
| Molecular Formula: | C26H34O7 |
| Solubility information: | DMSO, Methanol. alkaline aqueous solutions |
| Specifications | |
| Appearance: | Off-white powder |
| Purity: | At least 98% by TLC, HPLC |
| λmax: | 334, 349 （in Ethanol） |
| Melting point | 190°C-192°C |
| Solubility | |
| Storage | +4°c. Protect from light. Store in tightly sealed vial. |
| Applications | A crude preparation of Fumagillin is marketed under the trade name "Fumidil B". It is an effective treatment for intestinal microsporidiosis caused by Enterocytozoon bieneusi. Used to treat （） the Nosema disease in honey bees. Applied topically to the conjunctiva in the treatment of microsporidial keratoconjunctivitis. Once used to treat malaria. Since Fumidil B only contains about 3% of Fumagillin, it is not clear whether its therapeutic activity should be ascribed to Fumagillin. The Research grade Fumagillin is used in the angiogenesis research. In the connection to its anti angiogenetic capabilities, Fumagillin is mentioned as an potential anti-neoplastic antibiotic. Fumagillin is a starting material for several anticancer drug candidates, such as TNP-470. Fumagillin was also shown to be able to protect macrophages from the HIV infection |
| Warnings | Harmful if swallowed |
| Classification | fatty acid antibiotic antiprotozoal |
| Related products | |
| For Research use only. Not for Human or Drug use GMP/API grade available on request fumagillin by Fermentek is not produced from or contains any ingredients from animal origin. No genetically modified organisms are used. The Research grade （98% or better） Fumagillin is not intended for veterinary use. | |
| Publications | |
| Lefkove B, Govindarajan B, Arbiser JL. Fumagillin Review: an anti-infective as a parent molecule for novel angiogenesis inhibitors. Expert Rev Anti Infect Ther. 2007 Aug;5（4）:573-9. . | |
| Lee HW, Cho CS, Kang SK, Yoo YS, Shin JS, Ahn SK. Free Full Text Design, synthesis, and antiangiogenic effects of a series of potent novel fumagillin analogues. Chem Pharm Bull （Tokyo）. 2007 Jul;55（7）:1024-9. | |
| Winter PM, Neubauer AM, Caruthers SD, Harris TD, Robertson JD, Williams TA, Schmieder AH, Hu G, Allen JS, Lacy EK, Zhang H, Wickline SA, Lanza GM. Endothelial alpha（v）beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis. Arterioscler Thromb Vasc Biol. 2006 Sep;26（9）:2103-9. | |
| Didier PJ, Phillips JN, Kuebler DJ, Nasr M, Brindley PJ, Stovall ME, Bowers LC, Didier ES. Antimicrosporidial activities of fumagillin, TNP-470, ovalicin, and ovalicin derivatives in vitro and in vivo. Antimicrob Agents Chemother. 2006 Jun;50（6）:2146-55. | |
| Watanabe N, Nishihara Y, Yamaguchi T, Koito A, Miyoshi H, Kakeya H, Osada H. Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity. FEBS Lett. 2006 May 15;580（11）:2598-602. |
