| Source: | Penicillium expansum | | Synonyms | Clavacin, Claviformin, Mycoin C3 | | Description: | Patulin: a cytostatic, antibacterial mycotoxin. Inhibits potassium uptake, activates the p38 kinase. | | CAS number: | 149-29-1 | | Merck index: | 12, 7185 | | Molecular weight: | 154.1 | | Structure: | 
| | Molecular Formula: | C7H6O4 | Solubility
information: | Patulin is soluble in DMSO, Methanol, Ethanol, water | | Specifications | | | Appearance: | White crystalline solid. | | Purity: | At least 98% by TLC, HPLC | | λmax: | 276 | | Melting point | 105°C-111°C | | Solubility | Clear colorless solution at 10mg of Patulin in 1 ml of DMSO | | Storage | -20°C. Protect from light. | | Applications | | | Warnings | TOXIC. Patulin may be lethal if swallowed, inhaled or adsorbed through skin. Patulin has been proven to be carcinogenic and potentially mutagenic. | | Classification | Lactone Mycotoxin
Cell signaling reagent; apopotosis inducer | | Related products | | | | For Research use only. Not for Human or Drug use
GMP/API grade available on request
Patulin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. | | Publications | | | | Fuchs S, Sontag G, Stidl R, Ehrlich V, Kundi M, Knasmüller S.
Detoxification of patulin and ochratoxin A, two abundant mycotoxins, by lactic acid bacteria.
Food Chem Toxicol. 2008 Apr;46（4）:1398-407 | | | McLaughlin J, Lambert D, Padfield PJ, Burt JP, O'Neill CA.
Toxicol In Vitro. 2009 Feb;23（1）:83-9.
The mycotoxin patulin, modulates tight junctions in caco-2 cells. | | | Saxena N, Ansari KM, Kumar R, Dhawan A, Dwivedi PD, Das M.
Patulin causes DNA damage leading to cell cycle arrest and apoptosis through modulation of Bax, p（53） and p（21/WAF1） proteins in skin of mice.
Toxicol Appl Pharmacol. 2009 Jan 15;234（2）:192-201 | | | Wu TS, Liao YC, Yu FY, Chang CH, Liu BH.
Mechanism of patulin -induced apoptosis in human leukemia cells （HL-60）.
Toxicol Lett. 2008 Dec 15;183（1-3）:105-11 | | | Luft P, Oostingh GJ, Gruijthuijsen Y, Horejs-Hoeck J, Lehmann I, Duschl A.
Patulin influences the expression of Th1/Th2 cytokines by activated peripheral blood mononuclear cells and T cells through depletion of intracellular glutathione.
Environ Toxicol. 2008 Feb;23（1）:84-95. | |
