R-1 Methanandamide Phosphate

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产品名称：R-1 Methanandamide Phosphate

产品别名：R-1MAP;(R)-(+)-Arachidonyl-1'-Hydroxy-2'-Propylamide Phosphate;

CAS号：649569-33-5

英文别名：(2R)-2-[(5Z,8Z,11Z,14Z)-5,8,11,14-Icosatetraenoylamino]propyl dih ydrogen phosphate

分子量：441.5

分子式：C₂₃H₄₀NO₅P

纯度：≥98%

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保存方法：Store at -20℃

描述：Arachidonoyl ethanolamide (AEA) was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB₁ and CB₂) as Δ⁹-THC.^1,2 Since that time, a number of related endocannabinoids have been isolated, most notably 2-arachidonoyl glycerol (2-AG).² The phosphate ester of R-1 methanandamide, R-1MAP, has been tested as a water soluble prodrug analog of AEA.³ The activity of R-1MAP was essentially equivalent to that of AEA in the growth inhibition of C₆ glioma cells. However, when tested for inhibition of AEA binding to isolated rat brain CB₁ receptors, arachidonoyl ethanolamide phosphate (AEA-P) is about 5-fold less potent as an agonist with a K_i of about 200 nM.⁴ The phosphate esters of AEA and its analogs are also structural variants of lysophosphatidic acid (LPA). However, the effects of R-1MAP on the various LPA receptors have not been tested.

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