Latanoprost ethyl amide

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产品名称：Latanoprost ethyl amide

产品别名：Lat-NEt;

CAS号：607351-44-0

英文别名：(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpen tyl]cyclopentyl}-N-ethyl-5-heptenamide

分子量：417.6

分子式：C₂₅H₃₉NO₄

纯度：≥98%

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保存方法：Store at -20℃

描述：Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.¹ Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs.² Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo,³ studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 µg/g corneal tissue/hr.⁴ Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.

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