HMB-Val-Ser-Leu-VE

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试剂描述：

产品名称：HMB-Val-Ser-Leu-VE

产品别名：HMB-Val-Ser-Leu-VE

CAS号：862891-04-1

英文别名：HMB-Val-Ser-Leu-VE

分子量：505.6

分子式：C₂₆H₃₉N₃O₇

纯度：≥98%

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保存方法：Store at -20℃

描述：The 20S proteasome is a 700 kDa, multi-subunit cylinder-shaped protein that functions as the central protease within the ubiquitin-proteasome pathway utilized by cells for the regulated degradation of proteins.^1,2 HMB-val-ser-leu-VE is a tripeptide bearing a C-terminal vinyl ester which acts as a potent, selective inhibitor of the trypsin-like activity of the 20S proteasome. It inhibits the tryptic-like, chymotryptic-like, and post acidic activities of the purified 20S proteasome with IC₅₀ values of 0.33 µM, >10 µM, and >10 µM, respectively.³ HMB-val-ser-leu-VE is cell permeable and stable (t_½ ~6 hours) in in vitro assays.

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