Caylin-1

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产品名称：Caylin-1

产品别名：4-{[(4S,5R)-4,5-Bis(3,4-dichlorophenyl)-2-(2-isopropoxy-4-methoxy phenyl)-4,5-dihydro-1H-imidazol-1-yl]carbonyl}-2-piperazinone

CAS号：1207480-88-3

英文别名：4-{[(4S,5R)-4,5-Bis(3,4-dichlorophenyl)-2-(2-isopropoxy-4-methoxy phenyl)-4,5-dihydro-1H-imidazol-1-yl]carbonyl}-2-piperazinone

分子量：650.4

分子式：C₃₀H₂₈Cl₄N₄O₄

纯度：≥98%

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保存方法：Store at -20℃

描述：Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity.¹ Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, caylin-1 inhibits the growth of HCT116 cells with an IC₅₀ value of approximately 7 µM, making it about 7-fold less potent than nutlin-3 in the same assay. Interestingly, at concentrations at or below 1 µM, caylin-1 promotes the growth of HCT116 cells approximately 20% compared to untreated cells.² The mechanism of the growth promoting properties of caylin-1 have not yet been elucidated.

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