5-bromo-3-phenyl Salicylic Acid

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试剂描述：

产品名称：5-bromo-3-phenyl Salicylic Acid

产品别名：5-bromo-2-hydroxy-3-phenylbenzoic acid

CAS号：99514-99-5

英文别名：5-bromo-2-hydroxy-3-phenylbenzoic acid

分子量：293.1

分子式：C₁₃H₉BrO₃

纯度：≥95%

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保存方法：Store at -20℃

描述：The aldo-keto reductase (AKR) enzymes constitute a family of related NADP-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases (HSD), with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone.¹ In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function.^2,3,4,5 5-bromo-3-phenyl Salicyclic acid selectively inhibits AKR1C1 (K_i = 140 nM) over AKR1C2 (K₁ = 1.97 µM) and AKR1C3 (K_i = 21 µM).⁶ It does not inhibit AKR1C4 at 100 µM.⁶

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