4-Quinolone-3-Carboxamide CB2 Ligand

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

试剂描述：

产品名称：4-Quinolone-3-Carboxamide CB2 Ligand

产品别名：4Q3C CB₂ Ligand;

CAS号：1314230-69-7

英文别名：4-Quinolone-3-Carboxamide Derivative

分子量：422.6

分子式：C₂₆H₃₄N₂O₃

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20℃

描述：Cannabinoids (CBs) and their synthetic analogs produce biochemical and pharmacological effects by interacting with the central CB₁ and peripheral CB₂ receptors. The CB₂ receptor has emerged as a pharmacotherapeutic target for treating osteoporosis, as well as for eliciting antinociceptive effects in various models of pain. 4-Quinolone-3-carboxamide CB₂ ligand is a selective, high-affinity ligand of the CB₂ receptor, displaying a K_i value of 0.6 nM (K_i >10,000 nM for CB₁) in vitro. At a dose of 6 mg/kg, 4-quinolone-3-carboxamide CB₂ ligand exhibits antinociceptive activity in a formalin test of nocifensive response in mice. This analgesic affect is not significantly reversed by the CB₂ antagonist AM630 (Item No. 10006974), which suggests 4-quinolone-3-carboxamide CB₂ ligand may behave as an inverse agonist.¹

应用：见爱必信官网

产品信息订购：

产品更多信息请进入爱必信网站咨询