17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α

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产品名称：17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α

产品别名：17-trifluoromethylphenyl-13,14-dihydro trinor PGF_2α;

CAS号：294856-01-2

英文别名：(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-{(3R)-3-hydroxy-5-[3-(trifl uoromethyl)phenyl]pentyl}cyclopentyl]-5-heptenoic acid

分子量：458.5

分子式：C₂₄H₃₃O₅F₃

纯度：≥98%

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保存方法：Store at -20℃

描述：A number of 17-phenyl trinor prostaglandin F_2α (17-phenyl trinor PGF_2α) derivatives have been approved for the treatment of glaucoma.^1,2,3 Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.⁴ 17-trifluoromethylphenyl-13,14-dihydro trinor PGF_2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF_2α would act very much like the free acid of latanoprost.

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