磷酸化脊髓小脑失调症蛋白1抗体(Ser775)抗体

抗体（antibody）指机体的免疫系统在抗原刺激下，由B淋巴细胞或记忆细胞增殖分化成的浆细胞所产生的、可与相应抗原发生特异性结合的免疫球蛋白。主要分布在血清中，也分布于组织液及外分泌液中。
磷酸化脊髓小脑失调症蛋白1抗体(Ser775)抗体  产品信息：
中文名称：磷酸化脊髓小脑失调症蛋白1抗体   
英文名称：Anti-phospho-Ataxin 1(Ser775)
产品编号：byk-12534R
产品规格：0.1ml/0.2ml  
产品用途：科研实验
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磷酸化脊髓小脑失调症蛋白1抗体(Ser775)抗体  介绍：
Ataxin-1, also designated spinocerebellar ataxia type 1 protein (Sca-1), is differentially expressed and localizes to both the cytoplasm and the nucleus. Mutations in Ataxin-1 are associated with the onset of the autosomal dominant neurodegenerative disorder spinocerebellar ataxia type 1 (SCA-1), which is characterized by progressive neuronal loss in the cerebellum, muscle wasting and ataxia. In Purkinje cells, where SCA-1 is predominantly observed, Ataxin-1 has been shown to directly associate with the Purkinje-enriched leucine-rich acidic nuclear protein (LANP) and the nuclear matrix-associated protein promyelocytic leukemia protein PML. In SCA-1, Ataxin-1 is mutated to encode a polyglutamine protein that forms nuclear aggregates, which interact significantly more strongly with LANP and contribute to the pathogenesis of SCA-1.  
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
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