ZM 323881 hydrochloride,5-((7-苄氧基喹唑啉-4-基 )氨基)-4-氟-2-甲基苯酚盐酸盐,324077-30-7

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试剂描述：

产品名称：ZM 323881 hydrochloride

产品别名：4-Fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]phenol Hydrochloride

CAS号：324077-30-7

英文别名：4-Fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]phenol Hydrochloride

分子量：411.86

分子式：C₂₂H₁₈FN₃O₂•HCl

纯度：见爱必信官网

外观：Powder

保存方法：Desiccate at 4° C

描述：ZM 323881 hydrochloride is a potent and selective inhibitor of human Flk-1 (vascular endothelial growth factor receptor 2, VEGFR-2/KDR) activity. ZM 323881 hydrochloride inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC₅₀ = 8 nM). Selectively inhibits Flk-1 (VEGFR-2) (IC₅₀ = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases. ZM 323881 hydrochloride is an inhibitor of EGFR, Flg and PDGFR-β.

应用：A receptor tyrosine kinase inhibitor of VEGFR-2 (Flk-1), PDGFR-beta, EGFR, and FGFR1

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