trans-EKODE-(E)-Ib,9-oxo-11-(3-pentyloxiran-2-yl)undec-10-enoic acid,478931-82-7

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试剂描述：

产品名称：trans-EKODE-(E)-Ib

产品别名：9-oxo-11-(3-pentyloxiran-2-yl)undec-10-enoic acid

CAS号：478931-82-7

英文别名：9-oxo-11-(3-pentyloxiran-2-yl)undec-10-enoic acid

分子量：310.43

分子式：C₁₈H₃₀O₄

纯度：见爱必信官网

外观：见爱必信官网

保存方法：Store at -20° C

描述：During oxidative stress, the abundant unsaturated fatty acid linoleic acid undergoes lipid peroxidation to produce α,β-unsaturated epoxy-keto-octadecenoic acids (EKODEs). Nonenzymatic autooxidation of linoleic acid generates six major EKODE isomers, which differ from one another in the positioning and the orientation of the epoxy group relative to the keto moiety. trans-EKODE-(E)-Ib is a biologically active peroxidation product of linoleic acid that is characterized, structurally, by having a trans carbon-carbon double bond between the 9-keto and 12,13-epoxy groups. It activates an antioxidant response element (ARE) in neuronal cells and induces the expression of ARE-regulated cytoprotective genes like NQO1. This EKODE also stimulates the synthesis of aldosterone and corticosterone in adrenal cells when supplied at 1-5 μM. This effect appears to be mediated by a rise in intracellular calcium.

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