2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester,ethyl 2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate,1159576-98-3

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

试剂描述：

产品名称：2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester

产品别名：ethyl 2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate

CAS号：1159576-98-3

英文别名：ethyl 2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benzo[g]indole-3-carboxylate

分子量：379.8

分子式：C₂₂H₁₈ClNO₃

纯度：见爱必信官网

外观：见爱必信官网

保存方法：Store at -20° C

描述：5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. A potent, reversible inhibitor of 5-LO, both in cell-free assays (IC₅₀ = 86 nM) and in intact neutrophils (IC₅₀ = 230 nM). It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC₅₀ = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC₅₀ = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.

应用：见爱必信官网

产品信息订购：

产品更多信息请进入爱必信网站咨询