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试剂描述： 产品名称：Stat3 Inhibitor VIII, 5,15-DPP 产品别名：5,15-Diphenylporphyrin CAS号：22112-89-6 英文别名：5,15-Diphenylporphyrin 分子量：462.54 分子式：C32H22N4 纯度：>97% 外观：见爱必信官网 保存方法：Store at 4° C 描述：Stat3 Inhibitor VIII, 5,15-DPP is a cell-permeable porphyrin compound that binds Stat3 (STAT3, KD = 880 nM by SPR) and prevents Stat3 SH2 domain-mediated ligand binding (IC50 = 280 nM) and dimerization (~60% inhibition at 50 μM in HEK293), while exhibiting much reduced activity against STAT1 ligand binding (IC50 = 10 μM) and no activity againt Grb2 ligand binding even at concentrations as high as 20 μM. 5,15-DPP pre-treatment (50 μM) of MDA-MB-468 cultures is shown to greatly inhibit IL-6-induced Stat3, but not STAT1/5a/5b, nuclear translocation (by >90%) and nuclear Stat3 c-myc promoter binding activity, resulting in a more than 90% reduction in cellular c-myc protein level. 应用：A cell permeable Stat3 binding porphyrin 产品信息订购：
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