ent-Prostaglandin E2,7-[(1S,2S,3S)-3-hydroxy-2-[(3R)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid,65085-69-0

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试剂描述：

产品名称：ent-Prostaglandin E2

产品别名：Enantiomeric PGE2

CAS号：65085-69-0

英文别名：Enantiomeric PGE2

分子量：352.5

分子式：C₂₀H₃₂O₅

纯度：见爱必信官网

外观：见爱必信官网

保存方法：Store at -20° C

描述：Ent-Prostaglandin E2 is the enantiomer of enzymatically-derived prostaglandin E2 (PGE2; ). Both are optically pure compounds whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Significant amounts of racemic PGE2 are created in vitro in settings of oxidative stress via isoprostane pathway intermediates. Inhibition of COX-2 with Aspirin reportedly reduces thromboxane A2 synthesis by 90% and PGI2 by > 80%, however, the same concentration decreases PGE2 by only 60%; this may be at least partially explained by free radical-catalyzed formation of stereoisomers of PGE2. Ent-Prostaglandin E2 could potentially be used as an analytical standard in the deconvolution of these extremely relevant, but complex biochemical issues.

应用：The enantiomer of PGE2

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