20-hydroxy Prostaglandin E2,20-HYDROXY PROSTAGLANDIN E2,57930-95-7

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试剂描述：

产品名称：20-hydroxy Prostaglandin E2

产品别名：20-hydroxy PGE2

CAS号：57930-95-7

英文别名：20-hydroxy PGE2

分子量：368.5

分子式：C₂₀H₃₂O₆

纯度：见爱必信官网

外观：Solution

保存方法：Store at -20° C

描述：20-hydroxy Prostaglandin E2 is the putative first intermediate in the metabolism by cytochrome P450 of PGE2 . A similar compound, 19(R)-Hydroxy-prostaglandin E2 , has been shown to act as a potent smooth muscle relaxant and a selective EP2 receptor agonist, contrary to PGE2, which can activate a variety of prostanoid receptor types. Receptor binding studies indicate that although metabolites of prostaglandins typically bind to EP receptors with lower affinity, they might still play an important role in these biochemical pathways due to an increased half-life. It is difficult to distinguish effects brought on by parent compounds and metabolites for PGE2 systems due to the rapid and complex metabolism of PGE2.

应用：A metabolite of PGE2 by CytP450 - receptor binding assay results have not been published

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