SIRT1 Activator 3,N-cyclopentyl-2-diazenyl-1-(3-methoxypropyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide,839699-72-8

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试剂描述：

产品名称：SIRT1 Activator 3

产品别名：Sirtuin 1 Activator 3

CAS号：839699-72-8

英文别名：Sirtuin 1 Activator 3

分子量：367.44

分子式：C₂₀H₂₅N₅O₂

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外观：见爱必信官网

保存方法：Store at -20° C

描述：SIRT1 Activator 3 is a member of the sirtuins (SIRTs), a distinctive class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been illustrated to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. This compound has been shown to increase fluorescence by 233% in a SIRT1 activity assay, and to suppress TNF-α in a dose-dependent manner. In THP-1 cells, TNF-α levels decreased from 325 ρg/ml (control) to 104 and 53 ρg/ml with 20 and 60 μM of SIRT1 Activator 3, respectively. This activator also has shown a significant dose-dependent effect on fat mobilization in differentiated adipocytes, which indicates the potential of SIRT1 activators for obesity research, and may inhibit neurotoxicity of the prion protein.

应用：A SIRT1 activator which also inhibits TNF-α

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