CITCO,(E)-1-[6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]-N-[(3,4-dichlorophenyl)methoxy]methanimine,338404-52-7

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试剂描述：

产品名称：CITCO

产品别名：6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime

CAS号：338404-52-7

英文别名：6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime

分子量：436.74

分子式：C₁₉H₁₂Cl₃N₃OS

纯度：>98%

外观：见爱必信官网

保存方法：Store at 4° C

描述：

CITCO is a cell-permeable imidazothiazole compound that acts as a potent and selective agonist for the human MB67 (orphan nuclear constitutive androstane receptor, CAR) . CITCO also displays ~100-fold greater selectivity for MB67 (CAR) over xenobiotic pregnane X receptor (PXR) in transient transfection assays (EC₅₀ = 25 nM vs. 3 μM) and shows no detectable activity on 15 other nuclear receptors tested even at concentrations as high as 10 μM.

应用：A cell-permeable imidazothiazole compound that acts a CAR agonist

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