Butyrolactone I,[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]methyl (2R)-4-hydroxy-3-(4-hydroxyphenyl)-2-methyl-5-oxofuran-2-carboxylate,87414-49-1

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产品名称：Butyrolactone I

产品别名：Olomoucin

CAS号：87414-49-1

英文别名：Olomoucin

分子量：424.44

分子式：C₂₄H₂₄O₇

纯度：≥99%

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保存方法：Store at -20° C

描述：Butyrolactone I is a selective small molecule inhibitor of cyclin-dependent kinase (CDK) enzymes, specifically inhibiting Cdk2 and Cdc2 kinase. The inhibitory effect Butyrolactone I is due to competition with ATP binding at CDK. Activating phosphorylation of the transcription factor E2F-1 is blocked by Butyrolactone I. The cdc2-like kinase responsible for phosphorylation of tau protein is shown to be inhibited by Butyrolactone I - the phosphorylation and electrophoretic mobility shift of microtuble tau components in cerebral cells incubated with ATP were both suppressed by Butyrolactone I. In PANC-1 and AsPC-1 cells, Butyrolactone I demonstrates significant suppression of pRb phosphorylation and Cyclin A expression, upregulation of Bax expression, and downregulation of Bcl-2 expression. Butyrolactone I is an inhibitor of Cdk1, Cdk5 and cyclin B.

应用：An exogenous inhibitor of CDK cyclin-dependent kinases

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