Aminopurvalanol A,Aminopurvalanol A,(2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol,220792-57-4

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

试剂描述：

产品名称：Aminopurvalanol A

产品别名：(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol; NG-97

CAS号：220792-57-4

英文别名：(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol; NG-97

分子量：403.91

分子式：C₁₉H₂₆ClN₇O

纯度：见爱必信官网

外观：Pale yellow solid

保存方法：Store at 4° C

描述：Aminopurvalanol A is a cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI₅₀ ~ 1.8 μM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI₅₀ of 30 nM) Aminopurvalanol A acts as a reversible and ATP-competitive inhibitor of Cdks (IC₅₀ = 33 nM for cdc2 (Cdk1)/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~ 100-fold greater selectivity over a panel of kinases tested (IC₅₀ ≥ 2.4 μM). Aminopurvalanol A has been shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.

应用：A reversible and ATP-competitive inhibitor of Cdks

产品信息订购：

产品更多信息请进入爱必信网站咨询