Tpl2 Kinase Inhibitor,4-[(3-氯-4-基)氨基]-6-[(3-吡啶甲基)氨基]-1,7-萘啶-3-甲腈,871307-18-5

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产品名称：Tpl2 Kinase Inhibitor

产品别名：4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine

CAS号：871307-18-5

英文别名：4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine

分子量：404.83

分子式：C₂₁H₁₄ClFN₆

纯度：≥95%

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保存方法：Store at -20° C

描述：Tpl2 Kinase Inhibitor is a reversible naphthyridine ATP-competitive inhibitor of the enzyme Cot (Tpl2 kinase). The enzyme is a hematopoietically expressed serine-threonine kinase responsible for regulating tumor necrosis factor-α, toll-like receptor, and G protein–coupled receptor signaling. Studies suggest that Cot (Tpl2 kinase) inhibitor suppresses LPS-induced TNF-α production from primary human monocytes. In addition, Tpl2 kinase inhibitor causes an increase in 1,25-Dihydroxyvitamin D3 (1,25D)-induced differentiation of myeloid leukemia cells via inhibition of Cot (Tpl2 kinase).

应用：A reversible competitive inhibitor of Tpl2 kinase

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