PKR Inhibitor,Imidazolo-oxindole PKR inhibitor C16,608512-97-6

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试剂描述：

产品名称：PKR Inhibitor

产品别名：RNA-Dependent Protein Kinase Inhibitor

CAS号：608512-97-6

英文别名：RNA-Dependent Protein Kinase Inhibitor

分子量：268.29

分子式：C₁₃H₈N₄OS

纯度：≥90%

外观：orange to brown amorphous

保存方法：Store at 4° C

描述：

PKR Inhibitor is an imidazolo-oxindole derivative that has been shown to inhibit RNA-induced PKR autophosphorylation and rescue PKR-dependent translation block. The alpha subunit of the eukaryotic initiation factor 2 is phosphorylated by the PKR, which is an interferon-induced serine/threonine protein. PKR influences cytokine gene expression stimulated by the latent membrane protein 1 (LMP) in Epstein-Barr virus. Research shows that PKR inhibitor inhibits the activities of caspase-3 and caspase-8 and prevents increase in pT(451)-PKR and pS(194)-FADD levels in SH-SY5Y nuclei. It has been observed that PKR inhibitor may protect cells against ER stress induced cell damage.

应用：Inhibits RNA-induced PKR autophosphorylation, as well as caspase-3 and caspase-8

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