PDGFR Tyrosine Kinase Inhibitor III,4-(6,7-dimethoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide,205254-94-0

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

试剂描述：

产品名称：PDGFR Tyrosine Kinase Inhibitor III

产品别名：4-(6,7-dimethoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide

CAS号：205254-94-0

英文别名：4-(6,7-dimethoxyquinazolin-4-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide

分子量：485.5

分子式：C₂₇H₂₇N₅O₄

纯度：见爱必信官网

外观：见爱必信官网

保存方法：Store at 4° C

描述：PDGFR Tyrosine Kinase Inhibitor III is a cell-permeable, potent, selective, and ATP-competitive inhibitor of the PDGFR family of tyrosine kinases (IC₅₀ = 50 nM for PDGFR-α, 80 nM for PDGFR-β, 50 nM for c-Kit, and 230 nM for Flt-3/Flk-2). PDGFR Tyrosine Kinase Inhibitor III inhibits the activities of other kinases only at much higher concentrations (IC50 > 30μM for EGFR, FGFR, Src, PKA, and PKC). Reported to block PDGF-BB-induced proliferation of porcine aorta smooth muscle cells (IC₅₀ = 250 nM).

应用：An ATP-competitive PDGFR inhibitor

产品信息订购：

产品更多信息请进入爱必信网站咨询