Olomoucine II,2-[[[2-[[(1R)-1-(羟基甲基)丙基]氨基]-9-(1-甲基乙基)-9H-嘌呤-6-基]氨基]甲基]苯酚,500735-47-7

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试剂描述：

产品名称：Olomoucine II

产品别名：6-(2-Hydroxybenzylamino)-2(R)-[[1-hydroxymethyl)propyl]amino]-9-isopropylpurine

CAS号：500735-47-7

英文别名：6-(2-Hydroxybenzylamino)-2(R)-[[1-hydroxymethyl)propyl]amino]-9-isopropylpurine

分子量：370.45

分子式：C₁₉H₂₆N₆O₂

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20° C

描述：Olomoucine II is a selective inhibitor of Cdk1(CDK1)/cyclin B (IC₅₀ = 20 nM). Olomoucine II is a potent cytotoxin in tumor cells: IC₅₀ = 5.3 μM against MCF7 cells, IC₅₀ = 11.1 μM against K562 cells, IC₅₀ = 3.0 μM against CEM cells, IC₅₀ = 6.3 μM against HOS cells, and IC₅₀ = 6.3 μM against G361 cells.

应用：A selective inhibitor of CDK1/cyclin B and a potent cytotoxin in tumor cell lines

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