N-3-oxo-dodecanoyl-L-Homoserine lactone,3-氧代-N-[(3S)-四氢-2-氧代-3-呋喃基]十二酰胺,168982-69-2

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试剂描述：

产品名称：N-3-oxo-dodecanoyl-L-Homoserine lactone

产品别名：3-oxo-C12-HSL

CAS号：168982-69-2

英文别名：3-oxo-C12-HSL

分子量：297.39

分子式：C₁₆H₂₇NO₄

纯度：>98%

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保存方法：Store at -20° C

描述：N-3-oxo-dodecanoyl-L-homoserine lactone (3-oxo-C12-HSL) is one of the acylhomoserine lactone (AHL) molecules frequently identified in extracts of respiratory secretions from cystic fibrosis patients infected with P. aeruginosa and/or strains of the B. cepacia complex. It is involved in the activation of transcription factors NF-κB and AP-2, which in turn induce interleukin-8 production in human lung fibroblasts and epithelial cells, possibly contributing to the neutrophil infiltration and inflammation found in P. aeruginosa infections. N-3-oxo-dodecanoyl-L-Homoserine lactone may work to fight bacterial infection by quenching quorum sensing, a regulatory system used by bacterium to control gene expression in response to increasing cell density.

应用：An activator of transcription factors NF-κB and AP-2

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