N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO),(2S)-2-amino-5-(1-aminoethylideneamino)pentanoic acid,hydrochloride,150403-88-6

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试剂描述：

产品名称：N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO)

产品别名：L-NIO hydrochloride

CAS号：150403-88-6

英文别名：L-NIO hydrochloride

分子量：209.67

分子式：C₇H₁₅N₃O₂•HCl

纯度：≥95%

外观：见爱必信官网

保存方法：Store at -20° C

描述：N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO), is an inhibitor of NOS3 (nitric oxide synthase) in the vascular endothelium that can halt endothelium-dependent relaxation induced by acteylcholine and cause endothelium-dependent contraction in aortic rings. Mechanistic studies have noted that L-NIO inhibits Ca²⁺-dependent NOS3 (eNOS). The same experiment on rat aorta has shown L-NIO to display a capacity to induce a dose-dependent increase in mean systemic arterial blood pressure. In addition, research has shown L-NIO to be the most potent inhibitor of the neutrophil and J774 enzymes compared to its analogues L-NMMA, L-NAME, and L-NNA.

应用：An inhibitor of NOS3

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