MK 0524 sodium salt,Sodium [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3 ,4-tetrahydrocyclopenta[b]indol-3-yl]acetate,572874-50-1

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

试剂描述：

产品名称：MK 0524 sodium salt

产品别名：Laropiprant

CAS号：572874-50-1

英文别名：Laropiprant

分子量：457.88

分子式：C₂₁H₁₈ClFNO₄SNa

纯度：见爱必信官网

外观：Crystalline

保存方法：Store at -20° C

描述：

MK 0524 sodium salt is a potent, selective DP1 receptor antagonist with K_i values of 0.57 nM and 0.75 μM for the DP1 and DP2 receptors, respectively. It inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC₅₀ values of 0.09 and 4.0 nM, respectively. In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion. At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a murine model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia.

应用：A potent, selective DP1 receptor antagonist

产品信息订购：

产品更多信息请进入爱必信网站咨询