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试剂描述： 产品名称：Recombinant Human Phosphoinositide 3-kinase beta P110beta/p85alpha 产品别名：重组人磷酸肌醇3-激酶β p110β/p85a；rHu PI3Kb CAS号：见爱必信官网 英文别名：PI3Kb 分子量：见爱必信官网 分子式：见爱必信官网 纯度：0.9 外观：Sterile filtered liquid formualtion（0.9 mg/ml solution in PBS and 2mM MgCl2）. 保存方法：Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. 描述： The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin receptor substrate (IRS) proteins (e.g. IRS-1 and IRS-2). It was also shown that PI3Kb is involved in apoptosis in human colon carcinoma cells. Injection of neutralizing antibodies specific to p110b in WiDr, HCT116 and CO 115 adenocarcinoma cells inhibited de novo DNA synthesis. PI3Kb is the major PI3K isoform required for apoptotic cell and Fc-g receptor mediated phagocytosis shown for primary mouse macrophages and the Jurkat human leukemia T cell line. It was shown by several research groups that the catalytic subunit of PI3Kb can be activated by Gbg subunits of G-protein coupled receptors. Phosphoinositide 3-kinase beta Human Recombinant is a glycosilated protein having a molecular weight as follows: p85a chain 83.5 kDa, p110b chain 124.3 kDa. 应用：见爱必信官网 产品信息订购：
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