RETRA,2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-(3,4-dihydroxyphenyl)ethanone,hydrochloride,1036069-26-7

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试剂描述：

产品名称：RETRA

产品别名：2-(4,5-Dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone hydrochloride

CAS号：1036069-26-7

英文别名：2-(4,5-Dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone hydrochloride

分子量：305.8

分子式：C₁₁H₁₂ClNO₃S₂

纯度：≥98%

外观：见爱必信官网

保存方法：Store at 4° C

描述：This is a mutant p53-dependent activator of p73, an activator of p53-regulated genes, and a suppressor of mutant p53-bearing tumor cells. Greater than 50% of tumors express mutant p53 which is defective for the tumor-suppressor function and contributes to malignancy by blocking a p53 family member p73. Activation of p73 in human cancer produces a cytotoxic effect. RETRA increases the expression level of p73 and releases p73 from the inhibitory complex with mutant 53. This then produces a tumor-supressor effect, in vitro and in vivo.

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