CR8, (R)-Isomer,(2R)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol,294646-77-8

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

试剂描述：

产品名称：CR8, (R)-Isomer

产品别名：(2R)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol

CAS号：294646-77-8

英文别名：(2R)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol

分子量：431.5

分子式：C₂₄H₂₉N₇O

纯度：≥97%

外观：见爱必信官网

保存方法：Store at -20° C

描述：CR8, (R)-Isomer is a cell-permeable (R)-DRF053 analog that acts as an ATP-binding pocket-targeting CDK/CK1 dual-specific inhibitor (IC₅₀ = 0.09, 0.072, 0.041, 0.11, 1.10, 0.18, and 0.40 μM against CDK1/B (cyclin dependent kinase 1/B), CDK2/A (cyclin dependent kinase 2/A), CDK2/E (cyclin dependent kinase 2/E), CDK5/p25 (cyclin dependent kinase 5/p25), CDK7/H (cyclin dependent kinase 7/H), CDK9/T (cyclin dependent kinase 9/T), and CK1δ/ε, respectively). (R)-CR8 inhibits CDK/CK1 more effectively than (R)-Roscovitine, while maintaining similar selectivity profile over other types of kinases (IC₅₀ = 3.6, 3.6, and 12.0 μM against Dyrk1A, Erk2, and GSK-3α/β (glycogen synthase kinase-3α/β), respectively). Both (R)-CR8 and (S)-enantiomers are much more effective than (R)-Roscovitine in apoptosis induction in cell cultures.

应用：A cell-permeable, ATP-binding pocket-targeting CDK/CK1 dual-specific inhibitor

产品信息订购：

产品更多信息请进入爱必信网站咨询