Salinomycin monosodium salt hydrate,Salinomycin monosodium salt hydrate,55721-31-8(anhydrous)

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试剂描述：

产品名称：Salinomycin monosodium salt hydrate

产品别名：Salinomycin monosodium salt hydrate

CAS号：55721-31-8(anhydrous)

英文别名：Salinomycin monosodium salt hydrate

分子量：772.98

分子式：C₄₂H₆₉NaO₁₁

纯度：0.85

外观：见爱必信官网

保存方法：Store at -20° C

描述：

Cancer stems cells (CSCs) are a subpopulation of cells within tumors that drive tumor growth and recurrence. They are resistant to many current cancer treatments. Salinomycin (sodium salt) is an antibacterial and coccidiostat compound that shows selective toxicity for the CSCs that exist as a subpopulation within HMLER breast cancer cells (IC50s = ~24 versus ~90 μM).1 At 8 μM, salinomycin treatment of 4T1 and MCF7Ras breast cancer cell lines results in a ~2-fold and ~3-fold, respective reduction of CSCs relative to controls.1 Treatment of 5 mg/kg salinomycin in mice implanted with SUM159 human breast cancer cells inhibits mammary tumor growth and induces increased epithelial differentiation of tumor cells.

应用：An antibacterial and coccidiostat compound that shows selective toxicity for Cancer stems cells (CSCs)

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