D-erythro-Sphingosine,D-鞘氨醇,123-78-4

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试剂描述：

产品名称：D-erythro-Sphingosine

产品别名：Sphingosine, C18 chain; 2-Amino-4-octadecene-1,3-diol; trans-4-Sphingenine

CAS号：123-78-4

英文别名：Sphingosine, C18 chain; 2-Amino-4-octadecene-1,3-diol; trans-4-Sphingenine

分子量：299.49

分子式：C₁₈H₃₇NO₂

纯度：≥97%

外观：见爱必信官网

保存方法：Store at -20° C

描述：

D-erythro-Sphingosine is the natural isomer of sphingosine and acts as a potent inhibitor of protein kinase C (IC₅₀=1-3 μM), but does not inhibit protein kinase A or myosin light chain kinase, and activates casein kinase II. This compound has been shown to inhibit calmodulin-dependent enzymes, phosphatidate phosphohydrolase, ATPase, phosphocholine cytidylyltransferase (CTP), and phorbol dibutyrate binding in vitro in human platelets. D-erythro-Sphingosine is active in intact cells and has been identified as an endogenous constituent in HL-60 cells, neutrophils, rat liver, rat brain and mouse tissues.
Other activities of D-erythro-sphingosine include inhibition of phosphatidate phosphohydrolase, Na⁺,K⁺-ATPase, CTP:phosphocholine cytidylyltransferase, calmodulin-dependent enzymes, binding of factor VII to tissue factor, binding of thyrotropin releasing hormone to its receptor and activation of EGF receptor kinase, phospholipase D and casein kinase II.

应用：A potent, highly selective PKC inhibitor

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