CAY10595,2-[5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxospiro[indole-3,3'-pyrrolidine]-1-yl]acetic acid,916047-16-0

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试剂描述：

产品名称：CAY10595

产品别名：5-chloro-1'-[5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'pyrrolidine]-1(2H)-acetic acid

CAS号：916047-16-0

英文别名：5-chloro-1'-[5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'pyrrolidine]-1(2H)-acetic acid

分子量：451.23

分子式：C₂₀H₁₃Cl₂FN₂O₅

纯度：见爱必信官网

外观：A crystalline solid

保存方法：Store at -20° C

描述：CAY10595 is a mixture of isomers which acts as a potent CRTH2/DP₂ receptor antagonist (Ki = 10 nM). The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on eosinophils, basophils and Th2 cells where it mediates the chemotactic activity of PGD2.

应用：A CRTH2/DP2 receptor antagonist

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