2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid,7-[2-(3-hydroxyoctyl)-5-oxopyrrolidin-1-yl]heptanoic acid,64054-40-6

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产品名称：2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid

产品别名：7-[2-(3-hydroxyoctyl)-5-oxopyrrolidin-1-yl]heptanoic acid

CAS号：64054-40-6

英文别名：7-[2-(3-hydroxyoctyl)-5-oxopyrrolidin-1-yl]heptanoic acid

分子量：341.5

分子式：C₁₉H₃₅NO₄

纯度：≥96%

外观：见爱必信官网

保存方法：Store at -20° C

描述：2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor (Kι = 35 nM) relative to the EP1, EP2, and EP3 receptors (Kι = 3,000, 2,000, and >3,000 nM, respectively). This chemical stimulates cAMP formation in excised murine ovaries. Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that plays important roles in bone formation and resorption, cancer and atherosclerosis by elevating the second messenger cAMP.

应用：An analog of PGE2

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