15-keto Latanoprost,propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]hept-5-enoate,135646-98-9

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产品名称：15-keto Latanoprost

产品别名：propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]hept-5-enoate

CAS号：135646-98-9

英文别名：propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]hept-5-enoate

分子量：430.6

分子式：C₂₆H₃₈O₅

纯度：见爱必信官网

外观：A solution in methyl acetate

保存方法：Store at -20° C

描述：Latanoprost is an F-series prostaglandin (PG) analog that has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto latanoprost. 15-keto Latanoprost is a potential metabolite of latanoprost when administered to intact animals. 15-keto Latanoprost is one of the common minor impurities found in commercial preparations of bulk drug compounds. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye. 15-keto Latanoprost is also miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 µg/eye. Products of β-oxidation account for most of the metabolites from latanoprost recovered in plasma and urine. However, 15-keto latanoprost is a minor metabolite, which could be enhanced in situations where β-oxidation is reduced.

应用：A minor metabolite of latanoprost and an F-series prostaglandin analog

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