17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α,17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1.α.,1027401-98-4

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产品名称：17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α

产品别名：17-TFM-PGF1α

CAS号：1027401-98-4

英文别名：17-TFM-PGF1α

分子量：458.5

分子式：C₂₄H₃₃F₃O₅

纯度：见爱必信官网

外观：A solution in methyl acetate

保存方法：Store at -20° C

描述：A number of 17-aryl trinor and 16-aryloxy tetranor prostaglandin F2α derivatives have been approved for the treatment of glaucoma. These “ring” prostaglandin (PG) analogs have improved efficacy over the PGs with an n-alkyl lower side chain. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. 17-trifluoromethylphenyl-13,14-dihydro trinor PGF1α (17-TFM-PGF1α) is a typical “ring” analog reminiscent of the trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGF1α is saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the “ring” series of analogs, this modification has little impact on FP receptor binding. As an ocular hypotensive agent, it is expected that 17-TFM-PGF1α would act very much like the free acid of latanoprost.

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