D-Fructose 1,6-bisphosphate trisodium salt hydrate,D-Fructose 1,6-bisphosphate trisodium salt hydrate,38099-82-0(anhydrous)

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产品名称：D-Fructose 1,6-bisphosphate trisodium salt hydrate

产品别名：D(+)Fructofuranose 1,6-diphosphate trisodium salt; Harden-Young ester; Hexose diphosphate trisodium salt

CAS号：38099-82-0(anhydrous)

英文别名：D(+)Fructofuranose 1,6-diphosphate trisodium salt; Harden-Young ester; Hexose diphosphate trisodium salt

分子量：406.06

分子式：C₆H₁₁Na₃O₁₂P₂

纯度：≥98%

外观：Powder

保存方法：Store at -20° C

描述：D-Fructose-1,6-bisphosphate (FBP), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It may be used as an allosteric activator of enzymes such as pyruvate kinase and NAD+-dependent L-(+)-lactate dehydrogenase, as an inhibitor of acetate kinase and as a substrate to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1,6-bisphosphatase(s). FBP is studied as a neuroprotective agent in brain injury. Fructose-1,6-biphosphate, along with fructose-2,6-biphosphate, modulates the activity of phosphofructokinase-1 (PFK-1), the rate-limiting step in glycolysis. During glycolysis, aldolase splits Fructose-1,6-biphosphate into dihydroxacetone phosphate (DHAP) and glyceraldehyde phosphate. Fructose-1,6-biphosphate is also an allosteric activator of the M2 isoform of Pyruvate Kinase (PK-M2), the predominant form of pyruvate kinase in cancer cells.

应用：May be used as an allosteric activator of enzymes such as pyruvate kinase and NAD+-dependent L-(+)-lactate dehydrogenase

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