PTP1B Inhibitor,3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide,765317-72-4

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产品名称：PTP1B Inhibitor

产品别名：3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide

CAS号：765317-72-4

英文别名：3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide

分子量：741.5

分子式：C₂₆H₁₉Br₂N₃O₇S₃

纯度：≥95%

外观：见爱必信官网

保存方法：Store at -20° C

描述：PTP1B inhibitor blocks the activity of the PTP1B (Protein Tyrosine Phosphatase 1B), which is a key factor in the negative regulation of insulin and leptin signaling pathway. Molecular dynamic studies have shown that PTP1B inhibitor has strong binding and high selectivity due to the hydrogen bonding networks formed around the active sites. Cytotoxicity and low revival rates throughout clone generation and maintence result if PTP1B is over-expressed in CHO and HEK293 stable cell clones. Studies have shown that PTP1B inhibitor could dramatically magnify the membrane translocation of the key glucose transporter Glut4 in PTP1B-overexpressed CHO cells.

应用：A protein tyrosine phosphatase 1B enzyme inhibitor

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