CAY10594,N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]naphthalene-2-carboxamide,1130067-34-3

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试剂描述：

产品名称：CAY10594

产品别名：N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,​5]dec-​8-yl)ethyl]-2-naphthalenecarboxamide

CAS号：1130067-34-3

英文别名：N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,​5]dec-​8-yl)ethyl]-2-naphthalenecarboxamide

分子量：428.53

分子式：C₂₆H₂₈N₄O₂

纯度：见爱必信官网

外观：A crystalline solid

保存方法：Store at -20° C

描述：CAY10594 is a Phospholipase D (PLD) inhibitor. PLD is an enzyme that cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD (PLD1 and PLD2) have been identified, with multiple splice variants of each. Although the two isoforms share functional and structural features, they are regulated differently and apparently serve distinct biological roles. CAY10594 is a potent PC-PLD2 inhibitor in vitro (IC₅₀ = 140 nM). It also inhibits PC-PLD1 at higher concentrations (IC₅₀ = 5.1 μM). CAY10594 strongly inhibits the invasive migration of breast cancer cells in transwell assays, suggesting that PLD might be a useful target in blocking tumor cell invasion.

应用：A PC-PLD2 inhibitor which also prevents the invasive migration of breast cancer cells

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