D-myo-Inositol-1,3,4,5,6-pentaphosphate, sodium salt,

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产品名称：D-myo-Inositol-1,3,4,5,6-pentaphosphate, sodium salt

产品别名：

CAS号：见爱必信官网

英文别名：

分子量：690

分子式：C₆H₁₂O₂₁P₅•5Na

纯度：见爱必信官网

外观：A lyophilized powder

保存方法：Store at -20° C

描述：D-myo-Inositol-1,3,4,5,6-pentaphosphate, sodium salt is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals. It can be interconverted with Ins(3,4,5,6)P4 by a 1-kinase/1-phosphatase cycle, as well as with Ins(1,4,5,6)P4 in a 3-kinase/3-phosphatase cycle. Ins(1,3,4,5,6)P5 inhibits the phosphorylation and kinase activity of Akt/PKB, inducing apoptosis in ovarian, lung, and breast cancer cells. It displays antiangiogenic activity in vitro, blocking capillary tube formation of HUVEC, as well as antitumor effects against cancer xenografts in nude mices. Ins(1,3,4,5,6)P5 binds to the PH domain of Grp1.

应用：A soluble second messenger

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